How the Contract Vivarium Enabled a Biotech Company to Improve Results

The Client

A pharmaceutical drug development company in the preclinical trial phase of developing novel therapies based on CRISPR gene editing technology.

The Problem

The client outsourced in vivo rodent studies to a contract research organization (CRO), leading to poor results. The contract research organization failed to meet their needs, resulting in poor outcomes including delays and high failure rates.

The high failure rates in the preclinical testing were attributed to user error at the CRO due to lack of experience in the biomethodology essential to the development of the clients’ novel therapies. The long delays and high failure rates resulted in excessive budget spend and missed target dates on the research and development timeline.

empty vivarium

 Their in vivo strategy was failing.

Building their own vivarium was cost-prohibitive, would jeopardize their funding, and set their schedule back at least a year. Outsourcing to another contract research organization and hoping for better results was risky.


How could they minimize their financial and scientific risk and get their preclinical trials back on track?

The Solution: Own Your Science

With Mispro’s full-service contract vivarium, the client was able to focus on science, while Mispro took care of the rest.

Mispro Biotech offers vivarium services which allows clients to conduct their own in vivo animal studies and control their preclinical trials. Mispro manages the research environment, the care and handling of research animals, and the necessary regulatory and compliance oversight. High-quality, ethical care of animals, good laboratory practices (GLP), and a stable, efficient research environment impacts the quality of the science.

As a result, the client was able to launch quickly and scale their preclinical testing at their own pace. The client’s principal investigator (PI) handled the basic biomethodology to support their animal models studies in a fraction of the time they had spent waiting for results from the CRO.

Their in vivo preclinical research was back on track at Mispro Biotech.

The Results

Regaining control over their science, the client achieved dramatically improved results in each phase of their program. The client was able to track significant improvements in conducting their studies in Mispro’s research environment versus outsourcing to a CRO.


The client’s teams were able to work faster and more efficiently in Mispro’s contract vivarium, accelerating their timelines at every stage of research and increasing the study volume 6x.

Mispro’s pricing structure and value benefits allowed the client to decrease overall costs by 50%, saving more of their budget for research.

Mispro’s full service vivarium support resulted in a 70% reduction in failure to replicate preclinical in vitro proof of concept (PoC) trials during the client’s preclinical in vivo trials. 

Mispro’s contract vivarium services include:

Mispro’s facility, services and expertise has been a key factor in the success we’ve had with our in vivo program.
Principal Investigator,
Client Company

Are you ready to own your science?

About Mispro Biotech Services

Mispro Biotech Services is a Contract Vivarium Organization (CVO) that offers biopharmaceutical & life sciences companies access to coworking vivarium research facilities plus comprehensive laboratory animal & compliance oversight services supporting preclinical in vivo drug development. Established in 2003, and with locations in all major U.S. & Canadian biotech hubs, Mispro is North America’s leading contract vivarium provider.